Saddle up for a hearty family dinner with this Cattle Drive Casserole, lightened up with a turkey swap. This rustic “cowboy-style” bake combines all the comforting elements of a classic casserole: seasoned meat, tangy biscuit dough, cheese, and a creamy vegetable filling. It’s reminiscent of a pot pie but with a Southwest twist. By using ground turkey instead of beef, we reduce the fat content without sacrificing the savory flavor, creating a meal that is both wholesome and satisfying for hungry appetites.
Why You’ll Love This Recipe
Kid-Friendly Comfort
This dish is a hit with kids because of the biscuits baked right on top. It’s fun to eat and packed with familiar flavors like cheese and mild taco spices. The turkey is hidden in a creamy, veggie-loaded sauce, making it a great way to sneak in some nutrition (peppers, onions, corn) without complaints.
Easy Weeknight Bake
Using refrigerated biscuit dough is a brilliant shortcut that saves time on busy nights. You prepare the meat mixture in a skillet, transfer it to a baking dish, top with biscuits, and let the oven do the rest. It’s a complete meal in one pan—protein, starch, and veg all together.

Ingredients
- 1 lb ground turkey
- 1 can refrigerated biscuits (e.g., Grands)
- 1 medium onion, diced
- 1 medium green bell pepper, diced
- 1 packet taco seasoning
- 0.5 cup sour cream
- 0.5 cup mayonnaise
- 1.5 cups cheddar cheese, shredded
Instructions
- Preheat oven to 375°F. Brown turkey, onion, and peppers in a skillet.
- Stir in taco seasoning and water. Remove from heat.
- Mix in sour cream, mayo, and 1 cup cheese.
- Transfer to baking dish. Top with biscuit pieces and remaining cheese.
- Bake 20-25 minutes until biscuits are golden.
Ingredient Highlights & Substitutions
Essential Ingredients
Ground Turkey: Lean and mild, it takes on the flavors of the sauce.
Refrigerated Biscuits: Tube biscuits (like Pillsbury Grands) for the fluffy topping.
Bell Peppers & Onions: The “cattle drive” aromatic base.
Taco Seasoning: Flavor shortcut!
Sour Cream & Mayo: Creates the creamy binder for the filling.
Cheddar Cheese: Melted into the filling and on top.
Smart Substitutions
You can definitely use ground beef if you prefer the classic version. For the topping, homemade biscuit dough or even cornbread batter works beautifully. If you want to avoid mayo, use Greek yogurt for a protein boost and tangier flavor. Add black beans or corn to the filling for extra texture and fiber.
Step-by-Step Instructions
Prep Phase
Preheat oven to 375°F (190°C). Spray a 9×13 baking dish. Dice the onions and peppers. Cut the raw biscuits into quarters.
Cooking Phase
In a large skillet, brown the ground turkey with the onion and peppers until cooked through. Drain any liquid.
Stir in the taco seasoning and a splash of water (about 1/4 cup).
Remove from heat. Stir in the sour cream, mayonnaise, and half of the shredded cheese. Mix well.
Spread the turkey mixture into the baking dish. Scatter the biscuit pieces evenly over the top. Sprinkle with the remaining cheese.
Bake for 20-25 minutes, or until the biscuits are golden brown and cooked through (check the center biscuits to ensure they aren’t doughy).
Pro Tips for Perfect Results
Technique Secrets
Don’t overcrowd the biscuits. If you pack them too tight, the ones in the middle won’t bake properly. Leaving little gaps allows heat to circulate. Also, putting cheese on top of the biscuits helps flavor them, but watch that it doesn’t burn; tent with foil if needed.
Common Mistakes to Avoid
A common mistake is having a filling that is too runny. The sour cream/mayo mixture should bind it, not make it soupy. Drain the meat well before mixing.
| Nutrient | Amount per Serving |
|---|---|
| Calories | 420 kcal |
| Protein | 24g |
| Carbohydrates | 35g |
| Fat | 20g |
Serving Ideas & Pairings
Presentation & Plating
Scoop big portions onto plates. A drizzle of hot sauce or salsa on top cuts the richness.
Pairing Suggestions
Serve with a crisp green salad. If you like hearty casseroles, try our Ground Beef and Rice Casserole (Lean) for another comforting baked dish.
Frequently Asked Questions
Q1? Can I make it ahead?
Prepare the filling ahead, but don’t add the biscuits until you are ready to bake, or they will get soggy from the moisture.
Q2? Can I use Crescent rolls?
Yes! Unroll the sheet over the top instead of biscuit pieces for a pot-pie crust style.
Q3? Is it spicy?
Only if you use spicy taco seasoning. Mild is very family-friendly.
Conclusion
Cattle Drive Casserole (Turkey Swap) is a fun, filling, and easy dinner that brings the whole family to the table. It’s classic comfort food done right.
